|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The lncRNA FEZF1-AS1 promotes the progression of colorectal cancer through regulating OTX1 and targeting miR-30a-5p.
|
31270006 |
2020 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
The lncRNA FEZF1-AS1 promotes the progression of colorectal cancer through regulating OTX1 and targeting miR-30a-5p.
|
31270006 |
2020 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
RESULTS As a result, we identified a total of 263 dysregulated genes that may participate in the metastasis of ccRCC, and established a predictive signature relying on the expression of OTX1, MATN4, PI3, ERVV-2, and NFE4, which could serve as significant progressive and prognostic biomarkers for ccRCC.
|
31194719 |
2019 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
We have demonstrated that the differential gene expression for both OTX1 and OTX2 genes might be a useful molecular marker to distinguish the different types of sinonasal tumors.
|
30882801 |
2019 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
We selected nasal and sinonasal adenocarcinomas to investigate the expression of OTX1 and OTX2 genes through immunohistochemical and real-time PCR analyses.Both OTX1 and OTX2 were absent in all the samples of sinonasal Intestinal-Type Adenocarcinomas (ITACs).
|
30882801 |
2019 |
|
Olfactory Neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
OTX1 mRNA was identified only in Non-Intestinal Type Adenocarcinomas (NITACs) while OTX2 mRNA was expressed only in Olfactory Neuroblastomas (ONs).
|
30882801 |
2019 |
|
Medulloblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
OTX1 and OTX2 Genes in Medulloblastoma.
|
30797919 |
2019 |
|
Childhood Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
OTX1 and OTX2 Genes in Medulloblastoma.
|
30797919 |
2019 |
|
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
OTX1 and OTX2 Genes in Medulloblastoma.
|
30797919 |
2019 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In conclusion, our data indicated that OTX1 functions as a key regulator in tumor growth and metastasis of GC cells.
|
30066897 |
2018 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, our data indicated that OTX1 functions as a key regulator in tumor growth and metastasis of GC cells.
|
30066897 |
2018 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Dowregulation of OTX1 attenuates gastric cancer cell proliferation, migration and invasion.
|
30066897 |
2018 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, the inhibition of OTX1 led to increased GC cell apoptosis by upregulating cleaved PARP, cleaved caspase‑3 and Bax.
|
30066897 |
2018 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, the inhibition of OTX1 led to increased GC cell apoptosis by upregulating cleaved PARP, cleaved caspase‑3 and Bax.
|
30066897 |
2018 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Interestingly, no expression of both OTX genes were detected in sinonasal intestinal-type adenocarcinomas; only OTX1 was found in non-intestinal-type adenocarcinomas and OTX2 was selectively expressed in olfactory neuroblastomas.
|
28348423 |
2017 |
|
Olfactory Neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, no expression of both OTX genes were detected in sinonasal intestinal-type adenocarcinomas; only OTX1 was found in non-intestinal-type adenocarcinomas and OTX2 was selectively expressed in olfactory neuroblastomas.
|
28348423 |
2017 |
|
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
OTX1 and OTX2 as possible molecular markers of sinonasal carcinomas and olfactory neuroblastomas.
|
28348423 |
2017 |
|
Prostate specific antigen measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.
|
28139693 |
2017 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study.
|
28049011 |
2017 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study.
|
28049011 |
2017 |
|
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study.
|
28049011 |
2017 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Orthodenticlehomeobox 1 (OTX1) overexpression had previously been associated with the progression of several tumors.
|
27478331 |
2016 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Expression of OTX1 was positively correlated with nodal metastasis status (P = 0.009) and TNM staging (P = 0.001) in HCC tissues.
|
27478331 |
2016 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of OTX1 was positively correlated with nodal metastasis status (P = 0.009) and TNM staging (P = 0.001) in HCC tissues.
|
27478331 |
2016 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The current results enabled the authors to identify novel potential therapeutic targets and biomarkers in E-ACC and M-ACC individually, with the implication that EN1, DLX6, and OTX1 (orthodenticle homeobox 1) are potential drivers of these cancers.Cancer 2016;122:1513-22.© 2016 American Cancer Society.
|
26953815 |
2016 |